On client side, each user will have to run a signed program named "Setup-ConnectionClient.exe” as a pre-requisite.
This program is available on your server, in the TSplus program folder: C:\Program Files (x86)\TSplus\Clients\WindowsClient:
It is also available in C:\Program Files (x86)\TSplus\Clients\www\ConnectionClient, so your users can just run the program once on your web server address: http://xxxxxxxxxxx/ConnectionClient/Setup-ConnectionClient.exe
or by downloading it.
Note: Since TSplus 12.40, The Client Setup Program and the RemoteApp client setup have been merged and can be deployed with one single setup - so if you download the Connection Client Setup, there will be no need to download the RemoteApp Client one.